Genetic Variance in Heparan Sulfation Is Associated With Salt Sensitivity

20247 citationsJournal Articlehybrid Open Access

Authors

Jetta J. Oppelaar · United States Nuclear Regulatory Commission

Bart Ferwerda

Mohamed Romman · United States Nuclear Regulatory Commission

Ghazalah Sahebdin · United States Nuclear Regulatory Commission

Aeilko H. Zwinderman

Henrike Galenkamp

S. Matthijs Boekholdt · John Benjamins Publishing Company (Netherlands)

Bert‐Jan H. van den Born ·

Abstract

The C allele of rs2892799 in <i>NDST3</i> exhibits higher BP in high sodium conditions when compared with low sodium conditions, whereas no differences were detected for the T allele. Concomitantly, both alleles demonstrate distinct expressions of D0S0, which, in turn, correlates with sodium-mediated BP elevation. These findings underscore the potential significance of genetic glycosaminoglycan variation in human BP regulation.

Topics & Keywords

Sodium Intake and Health Ion Transport and Channel Regulation Renal function and acid-base balance

UN Sustainable Development Goals

Sustainable cities and communities

Publication Details

Published in: Hypertension

Volume 81, Issue 10, pp. 2101-2112

DOI: 10.1161/hypertensionaha.124.23421

Field-Weighted Citation Impact: 2.15