Spatial multi-omics reveal intratumoral humoral immunity niches associated with tertiary lymphoid structures in pancreatic cancer immunotherapy pathologic responders

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Authors

Dimitrios N. Sidiropoulos · Johns Hopkins University

Sarah M. Shin · Johns Hopkins University

Meredith Wetzel · Johns Hopkins University

Alexander A. Girgis · Johns Hopkins University

Daniel Bergman · Johns Hopkins University

Ludmila Danilova · Johns Hopkins University

Susheel Perikala

Abstract

We report a spatial multi-omics atlas of PDAC tumors from a series of immunotherapy neoadjuvant clinical trials. Intratumorally, pathologic responders exhibit mature TLS that propagate plasma cells into malignant niches. Our findings offer insights on the role of TLS-associated humoral immunity and stromal remodeling during immunotherapy treatment.

Topics & Keywords

Single-cell and spatial transcriptomics Cell Image Analysis Techniques Immunotherapy and Immune Responses

Publication Details

Published in: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.1101/2024.09.22.613714

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Spatial multi-omics reveal intratumoral humoral immunity niches associated with tertiary lymphoid structures in pancreatic cancer immunotherapy pathologic responders

Authors

Abstract

Topics & Keywords

Publication Details