Polygenic Scoring for Detection of Ascending Thoracic Aortic Dilation

20241 citationsJournal Articlegreen Open Access

Authors

John DePaolo · Jisc

Gina Biagetti · Institute of General & Endovascular Neurosurgery

Renae Judy · Jisc

Grace J. Wang · Institute of General & Endovascular Neurosurgery

John J. Kelly · Jisc

Amit Iyengar · Jisc

Nicholas Goel · Jisc

Abstract

We demonstrated that inclusion of a UK Biobank-derived PGS to the AORTA score confers a clinically meaningful improvement in model performance only among individuals genetically similar to European reference populations and may exacerbate existing health care disparities.

Topics & Keywords

Aortic Disease and Treatment Approaches Aortic aneurysm repair treatments Connective tissue disorders research

UN Sustainable Development Goals

Reduced inequalities

Publication Details

Published in: Circulation Genomic and Precision Medicine

Volume 17, Issue 5, pp. e004512-e004512

DOI: 10.1161/circgen.123.004512

Field-Weighted Citation Impact: 0.42