EZH2 functional dichotomy in reactive oxygen species-stratified glioblastoma

20244 citationsJournal Articlegreen Open Access

Authors

Lynnette Koh · National Neuroscience Institute

Qing You Pang · National Neuroscience Institute

Wisna Novera · National Neuroscience Institute

See Wee Lim · National Neuroscience Institute

Yuk Kien Chong · National Neuroscience Institute

Jinyue Liu · Agency for Science, Technology and Research

Samantha Ya Lyn Ang

Abstract

Our findings highlight the functional dichotomy of the EZH2 CXC domain in governing ROS-stratified therapeutic resistance, thereby advocating for the development of therapeutic approaches targeting its noncanonical activities and underscoring the significance of patient stratification methodologies.

Topics & Keywords

Epigenetics and DNA Methylation Cancer-related molecular mechanisms research Glioma Diagnosis and Treatment

UN Sustainable Development Goals

Life in Land

Publication Details

Published in: Neuro-Oncology

Volume 27, Issue 2, pp. 398-414

DOI: 10.1093/neuonc/noae206

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