Genomic Landscape of ctDNA and Real-World Outcomes in Advanced Endometrial Cancer

202411 citationsJournal Articlehybrid Open Access

Authors

Pamela Soberanis Pina · University Health Network

Keelia Clemens · Guardant (United States)

Adrian Bubie · Guardant (United States)

Brooke Grant · University Health Network

G. Clark Haynes · Guardant (United States)

Nicole Zhang · Guardant (United States)

Leylah Drusbosky ·

Abstract

This study is one of the largest cohorts of ctDNA currently reported in endometrial cancer. The presence of TP53 mutation and other comutations detected by ctDNA have a negative effect on outcomes. This report suggests that ctDNA analysis is feasible and could become a useful biomarker for endometrial cancer.

Topics & Keywords

Cancer Genomics and Diagnostics Cancer Cells and Metastasis Sarcoma Diagnosis and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 30, Issue 24, pp. 5657-5665

DOI: 10.1158/1078-0432.ccr-24-2105

Field-Weighted Citation Impact: 3.11