Antiproliferative Activity of Cephalotaxus Esters: Overcoming Chemoresistance

20241 citationsJournal Article

Authors

Vladimir Yong‐Gonzalez · Memorial Sloan Kettering Cancer Center

Constantin Radu · Memorial Sloan Kettering Cancer Center

Paul Calder · Memorial Sloan Kettering Cancer Center

David Shum · Memorial Sloan Kettering Cancer Center

Mark G. Frattini · Memorial Sloan Kettering Cancer Center

Hakim Djaballah · Memorial Sloan Kettering Cancer Center

Abstract

Taken together, our results confirm that HHT is a substrate for MDR1. It opens the door to a new opportunity to clinically evaluate HHT and its derivatives for the treatment of AML and other cancers.

Topics & Keywords

Biological Activity of Diterpenoids and Biflavonoids Natural product bioactivities and synthesis Fungal Plant Pathogen Control

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Combinatorial Chemistry & High Throughput Screening

Volume 28, Issue 7, pp. 1264-1275

DOI: 10.2174/0113862073322175240823104921

Field-Weighted Citation Impact: 0.23