P199 Our experience with endobronchial ultrasound-guided transbronchial mediastinal transbronchial cryobiopsy

<h3>Introduction</h3> Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the technique of choice in the evaluation of malignant lymph nodes and staging of lung cancer. However, more and more suitable and larger tissue samples are increasingly needed, in particular for molecular analysis, thus combinations of techniques such as EBUS-guided intrabronchial transbronchial intraganglionic cryobiopsy (Cryo-EBUS) have emerged. Our objective is to analyze the patients performed in our unit. <h3>Methods</h3> Descriptive study of 172 patients who underwent EBUS together with mediastinal intraganglionic cryobiopsy. General data, type of sedation, sample size, anatomopathological results, concordance between both techniques and complications were collected. <h3>Results</h3> Of the 172 patients, 66.27% were male with a mean age of 61.3±23.2 years. The procedure was performed under conscious sedation with midazolam and fentanyl in 40% of cases, midazolam and ketamine in 22% being the rest performed under general anesthesia. EBUS-TBNA was performed 112 times on subcarinal neuropathy, 28 cases on hilar adenopathy, 20 on right paratracheal and 12 on a mediastinal mass, on average 2.31 punctures were performed, the mean sample size was 0.3±0.05 cm, after which a 1.1mm cryoprobe was introduced for sample collection, taking an average of 3.13 samples with a mean size of 0.47±0.26cm to complete the study. Cryo-EBUS was adequate for diagnosis obtaining valid and sufficient material in 93.9% versus 62.2% of EBUS-TBNA (table 1), in addition 85% did not suffer complications. <h3>Conclusions</h3> The cost-effectiveness of Cryo-EBUS is very high. The combination of both techniques can be an advance in the diagnosis of diseases at an earlier stage, although a larger number of patients is needed to confirm the data.