Late Breaking Abstract - Exploring optimal management of mild to moderate long-COVID symptoms with OTC medication

<bold>Background:</bold> Long COVID (LC) refers to the sequel or development of new symptoms 3 months after initial COVID-19 infection, affecting more than 17 million people across the WHO European Region. Understanding use of over-the-counter (OTC) medication in LC is crucial due to its global impact and real-world use. <bold>Aims and Objective:</bold> The review aims to guide clinicians in understanding and managing LC symptoms using OTC medication. <bold>Method:</bold> A literature search was conducted upto May 27, 2024 in PubMed & EMBASE using keywords related to LC & OTC medication including naturals <bold>Results:</bold> The lack of a clear clinical definition makes management of LC symptoms challenging. The prevalence of LC varies from 5–30%, affecting major organ systems & patients’ quality of life (QoL). Common symptoms include fatigue, dyspnea, persistent cough, chest pain, myalgia, anxiety, fever. While no specific treatments are approved, OTC medications can help manage symptoms & improve patients QoL. Studies indicate that paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) can help with symptoms like fever or pain lasting ≥3 months after COVID-19. Also, OTC medications and naturals, like mucolytics, antitussives and antihistamines, may benefit for selected LC patients. Promising OTC medications may eventually be incorporated into evidence-based guidelines for managing certain LC symptoms <bold>Conclusion:</bold> LC imposes a significant medical burden on patients, of treatment without guidance affecting their QoL. While no specific treatments are approved, symptomatic management approaches can provide relief. Several OTC medications effectively address mild-to-moderate LC symptoms, including those related to colds, flu, fever and pain