The Basis of Cognitive and Behavioral Dysfunction in Amyotrophic Lateral Sclerosis

20245 citationsReviewgold Open Access

Authors

Alexander Bampton · University of Oxford

Caroline McHutchison · University of Stirling

Kevin Talbot · University of Oxford

Michael Benatar · University of Miami

Alexander G. Thompson · University of Oxford

Martin R. Turner · University of Oxford

Abstract

Longitudinal studies have been helpful in identifying several potential correlates of cognitive and behavioral dysfunction but have frequently been confounded by selection bias and inappropriate testing platforms. This review provides a framework for more robust assessment of clinicopathological associations of neuropsychological abnormalities in ALS in the future, advocating for greater utilization of pre-symptomatic C9orf72 repeat expansion-carrying cohorts.

Topics & Keywords

Amyotrophic Lateral Sclerosis Research Parkinson's Disease Mechanisms and Treatments Neurogenetic and Muscular Disorders Research

UN Sustainable Development Goals

Quality Education

Publication Details

Published in: Brain and Behavior

Volume 14, Issue 11, pp. e70115-e70115

DOI: 10.1002/brb3.70115

Field-Weighted Citation Impact: 1.86