Increased thermal stability and retained antibacterial properties in a sulbactam and amantadine salt: towards effective antibacterial–antiviral combination therapies

20242 citationsJournal Articlediamond Open Access

Authors

Josephine Bicknell · Reed College

Igor Bondarenko · Reed College

Alice Colatrella · Reed College

Elani J. Cabrera-Vega · Portland State University

Jesus Daniel Loya · Reed College

Delbert S. Botes · University of Missouri

Jay L. Mellies ·

Abstract

A clinically relevant multidrug solid comprising sulbactam (β-lactamase inhibitor) and amantadine (antiviral) displays enhanced thermal stability and sustained antibacterial activity compared to starting materials.

Topics & Keywords

Phenothiazines and Benzothiazines Synthesis and Activities Synthesis and biological activity Pharmacological Effects of Natural Compounds

Publication Details

Published in: RSC Pharmaceutics

Volume 1, Issue 5, pp. 958-962

DOI: 10.1039/d4pm00247d

Field-Weighted Citation Impact: 0.47

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Increased thermal stability and retained antibacterial properties in a sulbactam and amantadine salt: towards effective antibacterial–antiviral combination therapies

Authors

Abstract

Topics & Keywords

Publication Details