Pharmacokinetics of Oral Cannabinoid Δ8-Tetrahydrocannabivarin and Its Main Metabolites in Healthy Participants

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Authors

Cristina Sempio · University of Colorado Anschutz Medical Campus

Jorge Campos-Palomino · University of Colorado Anschutz Medical Campus

Jelena Klawitter · University of Colorado Anschutz Medical Campus

Erica N. Peters

Laura MacNair

Mehdi Haghdoost · Charlotte's Web (United States)

Marcel O. Bonn‐Miller · Charlotte's Web (United States)

Amy Harrison

Abstract

For the first time, we report the pharmacokinetics of Δ8-THCV and its major metabolites after oral administration in humans. Δ8-THCV AUC<sub>last</sub> showed dose linearity but the observed possible conversion to the Δ9-THCV isomer should be further studied.

Topics & Keywords

Cannabis and Cannabinoid Research Forensic Toxicology and Drug Analysis Psychedelics and Drug Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Pharmaceuticals

Volume 17, Issue 12, pp. 1603-1603

DOI: 10.3390/ph17121603

Field-Weighted Citation Impact: 0.45