Evaluation of effectiveness of Moringa concanensis leaves against Cisplatin induced Ototoxicity in wistar rats.

This study investigates the protective effects of Moringa concanensis ethanolic leaf extract (MCEE) against cisplatin-induced ototoxicity.Phytochemical screening of the extract revealed the presence of alkaloids, flavonoids, carbohydrates, tannins, and phenols.Distortion Product Otoacoustic Emissions (DPOAE)were measured pre-and post-treatment, with findings indicating a significant reduction in DPOAE values in cisplatin-treated groups.However, MCEE coadministration led to a marked recovery in DPOAE levels.The study provides evidence for the antioxidant potential of Moringa concanensis, suggesting its therapeutic potential for cisplatin-induced ototoxicity.