Prescription versus over-the-counter venotonics: HPLC-DAD and static digestive model simulation comparison

20240 citationsJournal Articlehybrid Open Access

Authors

Róbert Novotný · Institute of Clinical and Experimental Medicine

Matyáš Orsák · Czech University of Life Sciences Prague

J. Lachman · Czech University of Life Sciences Prague

Kotikova ZORA · Czech University of Life Sciences Prague

Barbora Novotná · Medicon

Jaroslav Hlubocký · General University Hospital in Prague

Jan Piťha

Abstract

Our experimental results show that the contents of both listed active substances, diosmin and hesperidin, met the declared amounts in all tested medicaments. Digestion simulation showed identical behaviour in prescription and OTC venotonics. The active substances could not be determined in the non-alkalized sample. Digestion did not affect the solubility of the tested drugs.

Topics & Keywords

Phytochemistry and biological activity of medicinal plants Essential Oils and Antimicrobial Activity Thermoregulation and physiological responses

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: International Angiology

Volume 43, Issue 5, pp. 469-475

DOI: 10.23736/s0392-9590.24.05291-x

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