Chronic nicotine exposure induces molecular and transcriptomic endophenotypes associated with mood and anxiety disorders in a cerebral organoid neurodevelopmental model

Collectively, our results demonstrate that nicotine-induced alterations occur acutely and persist at later stages of development. These findings validate an <i>in vitro</i> model of PNE to better comprehend the emergence of neuropsychiatric molecular and transcriptomic endophenotypes resulting from gestational nicotine exposure.