Longitudinal Tracking of ALK-Rearranged NSCLC From Plasma Using Circulating Tumor RNA and Circulating Tumor DNA

20253 citationsJournal Articlegold Open Access

Authors

Simon Heeke · The University of Texas MD Anderson Cancer Center

Saumil Gandhi · The University of Texas MD Anderson Cancer Center

Hai T. Tran · The University of Texas MD Anderson Cancer Center

Vincent K. Lam · Sidney Kimmel Comprehensive Cancer Center

Lauren A. Byers · The University of Texas MD Anderson Cancer Center

Don L. Gibbons · The University of Texas MD Anderson Cancer Center

Abstract

The inclusion of ctRNA in liquid biopsies increased detection of <i>ALK</i> rearrangements and detection at baseline was associated with significantly worse progression-free survival highlighting the added benefit of ctRNA.

Topics & Keywords

Cancer Genomics and Diagnostics Lung Cancer Treatments and Mutations Cholangiocarcinoma and Gallbladder Cancer Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JTO Clinical and Research Reports

Volume 6, Issue 4, pp. 100795-100795

DOI: 10.1016/j.jtocrr.2025.100795

Field-Weighted Citation Impact: 2.81