Targeting Pancreatic Cancer Cell Stemness by Blocking Fibronectin-Binding Integrins on Cancer-Associated Fibroblasts

20256 citationsJournal Articlegold Open Access

Authors

Chengsheng Wu · Sanford Consortium for Regenerative Medicine

Tami Von Schalscha · University of California San Diego

Diva Sansanwal · University of California San Diego

Chen Qian · University of California San Diego

Qinlin Jiang · University of California San Diego

Ryan M. Shepard · University of California San Diego

Hiromi I. Wettersten

Abstract

Simultaneous targeting of two integrins that function as receptors for FN, a protumor ECM protein, can prevent fibroblasts from supporting the malignant behavior of pancreatic cancer cells.

Topics & Keywords

Cell Adhesion Molecules Research Cellular Mechanics and Interactions Cancer Cells and Metastasis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer Research Communications

Volume 5, Issue 1, pp. 195-208

DOI: 10.1158/2767-9764.crc-24-0491

Field-Weighted Citation Impact: 9.47