Genetic predisposition to high circulating levels of interleukin 6 and risk for Alzheimer's disease. Discovery and replication

Genetic predisposition to higher circulating levels of IL-6 was associated with an increased risk for AD, supporting the role of IL-6-related pathways in AD pathogenesis, and suggesting that genetic predisposition to proinflammatory states might trigger or accelerate AD-related neuropathology.