Extracellular vesicle-mediated VEGF-A mRNA delivery rescues ischaemic injury with low immunogenicity

202532 citationsJournal Article

Authors

Yi You · Peking University

Yu Tian · Peking University

Rui Guo · Peking University

Junfeng Shi · The Ohio State University

Kwang Joo Kwak · The Ohio State University

Yuhao Tong · Peking University

Andreanne Poppy Estania · Peking University

Abstract

This study demonstrated that VEGF-A EV therapy offers efficient, dose-dependent VEGF-A protein formation with low immunogenicity, resulting in new vessel formation in murine models of ischaemic vascular disease.

Topics & Keywords

Extracellular vesicles in disease Cardiovascular Effects of Exercise CAR-T cell therapy research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: European Heart Journal

Volume 46, Issue 17, pp. 1662-1676

DOI: 10.1093/eurheartj/ehae883

Field-Weighted Citation Impact: 26.08