Monocyte STAT1 phosphorylation and treatment response of JAK inhibitors in chronic nonbacterial osteomyelitis

20250 citationsJournal Articlegold Open Access

Authors

Motoshi Sonoda · Kyushu University

Keishiro Kinoshita · Kyushu University

Nobutaka Harada · Kyushu University

Sung‐Yeon Park · Kyushu University

Shunichi Adachi · Kyushu University

Yutaro Yada · Kyushu University

Katsuhide Eguchi ·

Abstract

The monocyte pSTAT1 levels after IFNγ stimulation reflect the activity of CNO, indicating the diagnostic utility as well as the monitoring effect of disease control. Adjunctive JAK inhibitors successfully controlled inflammation in treatment-resistant cases. Rapid pSTAT1 testing may help reduce osteo-articular complications, although the long-term adverse effects and resistance should be further investigated.

Topics & Keywords

Osteomyelitis and Bone Disorders Research Infectious Diseases and Tuberculosis Spondyloarthritis Studies and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Pediatric Rheumatology

Volume 23, Issue 1, pp. 6-6

DOI: 10.1186/s12969-025-01059-6

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