Congestion Enriches Intra-hepatic Macrophages Through Reverse Zonation of CXCL9 in Liver Sinusoidal Endothelial Cells

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Authors

Siyuan Ma · Vanderbilt University Medical Center

Nawras W. Habash · Children's Hospital of Philadelphia

Mrunal Dehankar · Mayo Clinic

Nidhi Jalan‐Sakrikar · Mayo Clinic

Shawna A. Cooper · Mayo Clinic

Abid Anwar · Mayo Clinic

Sofía Jerez ·

Abstract

CXCL9 derived from peri-central LSECs enriches intra-hepatic macrophages in CH and FALD, contributing to congestive fibrosis and PHTN. Strategies to target LSEC-derived CXCL9 may prevent the progression of CH and FALD.

Topics & Keywords

Liver Disease Diagnosis and Treatment Liver physiology and pathology Phagocytosis and Immune Regulation

Publication Details

Published in: Cellular and Molecular Gastroenterology and Hepatology

Volume 19, Issue 7, pp. 101475-101475

DOI: 10.1016/j.jcmgh.2025.101475

Field-Weighted Citation Impact: 10.71

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Congestion Enriches Intra-hepatic Macrophages Through Reverse Zonation of CXCL9 in Liver Sinusoidal Endothelial Cells

Authors

Abstract

Topics & Keywords

Publication Details