A wireless, 60-channel, AI-enabled neurostimulation platform

Abstract Objective Closed-loop neuromodulatory therapies require devices that can both decode ongoing brain states and deliver multi-site stimulation. Methods We describe the Smart Neurostimulation System (SNS), a cranially mounted implant with 60 configurable recording/stimulation channels, inductive power, and onboard spectral-feature classification. In three freely-moving sheep we streamed local-field potentials and conducted two parameter sweep experiments. Results Cross-validated movement classifiers achieved an average AUC > 0.95. Increasing stimulation amplitude and frequency produced post-stimulation elevations in α -band (8-12 Hz) and γ -band (78-82 Hz) power at most target locations. Conclusion The SNS unifies high-density sensing, real-time brain state decoding, and programmable closed-loop stimulation in a single device, demonstrating behavioral-state prediction and parameter-dependent neuromodulation in vivo. Significance These findings establish a preclinical foundation for biomarker-guided stimulation targeting distributed cortical networks underlying memory and cognition. Highlights Wireless 60-channel implant enables simultaneous sensing and stimulation vine study demonstrates reliable classification of movement and stimulation-related modulation of spectral activity The SNS represents a platform for biomarker-guided neuromodulation therapies