Reply on RC2

<strong class="journal-contentHeaderColor">Abstract.</strong> Combining high-field high-resolution NMR with an evolution of spin systems at low magnetic field offers many opportunities for the investigation of molecular motions, hyperpolarization and the exploration of field-dependent spin dynamics. Fast and reproducible transfer between high and low fields is required to minimize polarization losses due to longitudinal relaxation. Here, we introduce a new design of a sample shuttle that achieves remarkably high speeds, v_max ~ 27 m.s^-1. This hybrid pneumatic/mechanical apparatus is compatible with conventional probes at the high-field center. We show applications to water relaxometry in solutions of paramagnetic ions, high-resolution proton relaxometry of a small molecule and sample shuttling of a solution of a 42 kDa protein. Importantly, this fast sample shuttle system is narrow, with a diameter d = 6 mm for the sample shuttle container based on a standard 5 mm outer diameter glass tube, which should allow near access to the sample for magnetic manipulation at low field.