WOUND MANAGEMENT, HEALING, AND EARLY PROSTHETIC REHABILITATION: PART 3 - A SCOPING REVIEW OF CHEMICAL BIOMARKERS

Predictive biomarkers identify comorbidities that may hinder healing, aiding in pre-amputation risk assessment for poor recovery. Indicative biomarkers monitor key biological healing processes, such as angiogenesis (the formation of new blood vessels), wound contraction, and inflammation. Diagnostic biomarkers provide direct insights into tissue composition and cellular-level healing. Integrating these biomarkers into post-amputation assessments enables continuous monitoring of the healing process while accounting for comorbidities, enhancing the objectivity of post-surgical healing management and ensuring more effective, personalized rehabilitation strategies.