Presence of Tertiary Lymphoid Structures and Exhausted Tissue-Resident T Cells Determines Clinical Response to PD-1 Blockade in Renal Cell Carcinoma

202524 citationsJournal Articlegreen Open Access

Authors

Miya B. Hugaboom · Yale Cancer Center

Lena V. Wirth · Yale Cancer Center

Kelly Street · University of Southern California

Neil Ruthen · Cornell University

Opeyemi A. Jegede · Dana-Farber Cancer Institute

Nicholas R. Schindler · Yale Cancer Center

Valisha Shah ·

Abstract

We describe a paradigm wherein combined high TLS and low tissue-resident exhausted CD8+ T cells are required for optimal response to PD-1 blockade in RCC. This analysis identifies key determinants of response to PD-1 blockade in advanced RCC and suggests avenues for future immune modulation through rational combination therapy strategies.

Topics & Keywords

Cancer Immunotherapy and Biomarkers Renal cell carcinoma treatment Single-cell and spatial transcriptomics

UN Sustainable Development Goals

No poverty

Publication Details

Published in: Cancer Discovery

Volume 15, Issue 5, pp. 948-968

DOI: 10.1158/2159-8290.cd-24-0991

Field-Weighted Citation Impact: 24.50