Combined effects of cannabidiol and Δ9-tetrahydrocannabinol alleviate migraine-like symptoms in mice

202510 citationsJournal Articlehybrid Open Access

Authors

Erik Zorrilla · University of Iowa

Georgii Krivoshein · Leiden University Medical Center

Adisa Kuburas · University of Iowa

Maarten Schenke · Leiden University Medical Center

Christian Pina · University of Iowa

Sandra H. van Heiningen · Leiden University Medical Center

Jayme S. Waite

Abstract

A 100:1 ratio of CBD:THC has a beneficial effect on some of the most bothersome migraine-related symptoms in three mouse models. Our findings support a potential therapeutic efficacy of combined CBD and THC treatments.

Topics & Keywords

Cannabis and Cannabinoid Research Migraine and Headache Studies Neuroscience of respiration and sleep

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cephalalgia

Volume 45, Issue 2, pp. 3331024251314487-3331024251314487

DOI: 10.1177/03331024251314487

Field-Weighted Citation Impact: 13.51