Multiplexed epigenetic memory editing using CRISPRoff sensitizes glioblastoma to chemotherapy

202511 citationsJournal Articlehybrid Open Access

Authors

Katie Lin · University of California, San Francisco

Christopher Zou · University of California, San Francisco

A L Hubbard · University of California, San Francisco

Sasha Sengelmann · University of California, San Francisco

Laine Goudy · Gladstone Institutes

I‐Ching Wang · University of California, San Francisco

Rohit Sharma

Abstract

Transient delivery of a site-specific epigenetic memory can induce stable, complete, and multiplexed suppression of target genes for therapeutic application in GBM.

Topics & Keywords

CRISPR and Genetic Engineering Advanced biosensing and bioanalysis techniques Glioma Diagnosis and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neuro-Oncology

Volume 27, Issue 6, pp. 1443-1457

DOI: 10.1093/neuonc/noaf055

Field-Weighted Citation Impact: 8.91