ESCALÓN: A Prospective Randomized Trial of Corneal Endothelial Cell Therapy in Subjects With Corneal Edema

20255 citationsJournal Articlehybrid Open Access

Authors

Edward J. Holland · Cincinnati Eye Institute

Elizabeth Yeu · Virginia Eye Consultants

Matthew Giegengack · Wake Forest University

John P. Berdahl · Vance Thompson Vision

E. Jordan

Rodrigo Quesada · Universidad Nueva San Salvador

Gabriel Quesada · Universidad Nueva San Salvador

Abstract

The study demonstrated that transplantation of cultured CECs with Y-27632 was safe and efficacious across all evaluated doses of Y-27632. No clinically meaningful dose response was seen for Y-27632. This innovative therapeutic approach represents a promising option for treating corneal edema arising from corneal endothelial dysfunction.

Topics & Keywords

Corneal surgery and disorders Corneal Surgery and Treatments Glaucoma and retinal disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cornea

Volume 44, Issue 12, pp. 1497-1507

DOI: 10.1097/ico.0000000000003844

Field-Weighted Citation Impact: 6.63