Preclinical Alzheimer's disease shows alterations in circulating neuronal‐derived extracellular vesicle microRNAs in a multiethnic cohort

202510 citationsJournal Articlehybrid Open Access

Authors

Paolo Reho · Columbia University

Vrinda Kalia · Columbia University

Gabriela L. Jackson · Columbia University

Fang Wang · Columbia University

Erez Eiten · NeuroBioTex (United States)

Kasey Brennan · Harvard University

Adam M. Brickman ·

Abstract

Neuronal-derived extracellular vesicles (NDEVs) carry potential brain biomarkers. We tested the association between NDEV microRNAs (miRNAs) and Alzheimer's disease (AD). Fourteen NDEV miRNAs were associated with AD. Preclinical AD displayed more pronounced transcriptional changes than clinical AD. miRNA-target genes were enriched in pathways associated with neurodegeneration.

Topics & Keywords

Extracellular vesicles in disease Neuroinflammation and Neurodegeneration Mechanisms MicroRNA in disease regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Alzheimer s & Dementia

Volume 21, Issue 3, pp. e70050-e70050

DOI: 10.1002/alz.70050

Field-Weighted Citation Impact: 7.89