Left Atrial Appendage Occlusion in Solid Organ Transplant Patients

Percutaneous left atrial appendage occlusion (LAAO) is increasingly used to provide nonpharmacologic stroke prevention in patients with atrial fibrillation, particularly patients at high risk for complications of anticoagulation. Randomized controlled trials establishing LAAO safety and efficacy excluded solid organ transplantation recipients; thus, the role of LAAO in these patients is poorly understood. We present a series of patients with a history of solid organ transplantation who underwent LAAO and include patient-level data on indication, safety, and long-term outcomes. Our cohort demonstrated excellent efficacy and procedural safety with successful implantation in all cases, no major periprocedural complications, and successful discontinuation of systemic anticoagulation.