The association between undetected heteroresistance and antibiotic treatment failure in complicated urinary tract infection

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Authors

Carter N. Abbott · Emory University

Anahat Dhillon · Emory University

Sushma Timalsina · Emory University

Elise Furr · Emory University

Patrick Vélicitat · Ally Therapeutics (United States)

Adam Belley · Ally Therapeutics (United States)

Navaneeth Narayanan ·

Abstract

These data demonstrate that patients infected with a piperacillin/tazobactam heteroresistant isolate are at an increased risk for piperacillin/tazobactam treatment failure. The results help contextualize commonly observed unexpected antibiotic treatment failure and highlight heteroresistance as a potential cause.

Topics & Keywords

Urinary Tract Infections Management Clostridium difficile and Clostridium perfringens research Bacterial Identification and Susceptibility Testing

Publication Details

Published in: medRxiv

DOI: 10.1101/2025.03.11.25323422

Command Palette

The association between undetected heteroresistance and antibiotic treatment failure in complicated urinary tract infection

Authors

Abstract

Topics & Keywords

Publication Details