CircPVT1 weakens miR-33a-5p unleashing the c-MYC/GLS1 metabolic axis in breast cancer

202512 citationsJournal Articlegold Open Access

Authors

Alina Catalina Palcau · San Gallicano Hospital

Claudio Pulito · Istituti di Ricovero e Cura a Carattere Scientifico

Valentina De Pascale · Istituti di Ricovero e Cura a Carattere Scientifico

Luca Casadei · Sapienza University of Rome

Mariacristina Valerio · Sapienza University of Rome

Andrea Sacconi

Valeria Canu · Istituti di Ricovero e Cura a Carattere Scientifico

Abstract

In aggregate, our findings unveil the circPVT1/miR-33a-5p/Myc/GLS1 axis as a pro-tumorigenic metabolic event sustaining breast cancer transformation with potential therapeutic implications.

Topics & Keywords

Circular RNAs in diseases MicroRNA in disease regulation RNA modifications and cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Experimental & Clinical Cancer Research

Volume 44, Issue 1, pp. 100-100

DOI: 10.1186/s13046-025-03355-1

Field-Weighted Citation Impact: 9.47