Microglial ER stress response via IRE1α regulates diet-induced metabolic imbalance and obesity in mice

20255 citationsJournal Articlegold Open Access

Authors

Lukas Stilgenbauer · Rehabilitation Institute of Michigan

Qian Chen · DMC University Laboratories

D Pungi · Wayne State University

Natasha Maria James · Rehabilitation Institute of Michigan

HASHAN M. JAYARATHNE · Detroit R&D (United States)

Lisa Koshko · Rehabilitation Institute of Michigan

Sydney Scofield

Abstract

Our findings reveal that IRE1α-mediated ER stress response in microglia significantly contributes to hypothalamic inflammation and systemic metabolic dysfunction in response to HFD, particularly in males, demonstrating an important role of microglial ER stress response in diet-induced obesity and metabolic diseases.

Topics & Keywords

Neuroinflammation and Neurodegeneration Mechanisms Nuclear Receptors and Signaling Hormonal Regulation and Hypertension

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Molecular Metabolism

Volume 95, pp. 102128-102128

DOI: 10.1016/j.molmet.2025.102128

Field-Weighted Citation Impact: 4.22