Sexually dimorphic effects of angiopoietin-like 2 on energy metabolism and hypothalamic neuropeptide regulation

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Authors

Romane Manceau · Université de Montréal

P. P. Anthony · TransCanada (Canada)

Cécile Hryhorczuk · Centre Hospitalier de l’Université de Montréal

Pauline Labbé · Montreal Heart Institute

Nathalie Thorin‐Trescases · Montreal Heart Institute

Stephanie Fulton · Université de Montréal

Éric Thorin

Abstract

Angptl2 KD improved diet-induced obesity and associated metabolic dysfunction in male mice. The lack of similar changes in female mice and divergent MBH neuropeptide profile suggest that sex-dependent mechanisms underly the anabolic effects of this proinflammatory adipokine.

Topics & Keywords

Lipid metabolism and disorders Apelin-related biomedical research Adipose Tissue and Metabolism

Publication Details

Published in: International Journal of Obesity

Volume 49, Issue 6, pp. 1116-1124

DOI: 10.1038/s41366-025-01754-0

Field-Weighted Citation Impact: 1.46

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Sexually dimorphic effects of angiopoietin-like 2 on energy metabolism and hypothalamic neuropeptide regulation

Authors

Abstract

Topics & Keywords

Publication Details