Oral Swab Testing With Xpert MTB/RIF Ultra for the Diagnosis of Tuberculosis in Children Aged &lt;5 Years in Uganda: An Exploratory Interim Analysis of Diagnostic Accuracy in the NOD-pedFEND Cohort

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Authors

Nisreen Khambati · University of Oxford

Kanyange Angel Moureen · Makerere University

Francesca Wanda Basile · University of Oxford

Rudie Desravines · Frontier Science & Technology Research Foundation

Nathan J. Mudrak · University of Oxford

R Post · Frontier Science & Technology Research Foundation

Emmanuel Nasinghe

Abstract

The low sensitivity of Ultra on double swabs precludes its role as a principal diagnostic approach in young children. However, detection of tuberculosis in children who were not otherwise microbiologically diagnosed suggests the utility of oral swabs as add-on samples to increase yield.

Topics & Keywords

Tuberculosis Research and Epidemiology Pneumonia and Respiratory Infections HIV/AIDS oral health manifestations

Publication Details

Published in: Open Forum Infectious Diseases

Volume 12, Issue 4, pp. ofaf206-ofaf206

DOI: 10.1093/ofid/ofaf206

Field-Weighted Citation Impact: 4.20

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Oral Swab Testing With Xpert MTB/RIF Ultra for the Diagnosis of Tuberculosis in Children Aged &amp;lt;5 Years in Uganda: An Exploratory Interim Analysis of Diagnostic Accuracy in the NOD-pedFEND Cohort

Authors

Abstract

Topics & Keywords

Publication Details

Oral Swab Testing With Xpert MTB/RIF Ultra for the Diagnosis of Tuberculosis in Children Aged <5 Years in Uganda: An Exploratory Interim Analysis of Diagnostic Accuracy in the NOD-pedFEND Cohort