Early new bone formation in ovine intramuscular defects: comparison between different silicate-containing calcium phosphate synthetic bone grafts

Implantation in ovine intramuscular defects was found to be an effective model to differentiate the relative bone forming potential of three silicate calcium phosphate bone grafts, particularly using a short implantation time of only 6 weeks. Positive outcomes in such a pre-clinical model when evaluating synthetic bone graft substitutes may be clinically relevant to their potential use in challenging bone defects.