Characteristics of cortical thickness in treated HIV-infected individuals with and without cognitive impairment

The cortical thickness thinning was observed in the frontal and limbic systems in both ANI and CI. Meanwhile, the thickening of the insular cortex may represent mild neuroinflammation or a transient compensatory mechanism. This study provides new insights into the neural mechanisms underlying HIV-related cognitive impairment and highlights the importance of cortical thickness alteration patterns when assessing cognitive function of PLWH.