Targeting FASN enhances cisplatin sensitivity via SLC7A11-mediated ferroptosis in cervical cancer

202510 citationsJournal Articlegold Open Access

Authors

Xiaojun Wang · Sun Yat-sen University

Qiqiao Du · Sun Yat-sen University

Qiuwen Mai · Sun Yat-sen University

Qiaojian Zou · Sun Yat-sen University

Shuyi Wang · Qingdao University

Xiaoying Lin · Sun Yat-sen University

Qianrun Chen ·

Abstract

Targeting FASN enhances cisplatin sensitivity in CC by promoting SLC7A11-mediated ferroptosis. TVB-2640 combined with cisplatin had superior synergistic antitumor effects in cisplatin-resistant CC models.

Topics & Keywords

Ferroptosis and cancer prognosis Cancer, Lipids, and Metabolism RNA modifications and cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Translational Oncology

Volume 56, pp. 102396-102396

DOI: 10.1016/j.tranon.2025.102396

Field-Weighted Citation Impact: 15.20