Maternal Tmprss6 is required for hepcidin suppression and fetal health

20251 citationsJournal Articlehybrid Open Access

Authors

Katherine Fielding · Walter and Eliza Hall Institute of Medical Research

Cavan Bennett · Walter and Eliza Hall Institute of Medical Research

Anne Pettikiriarachchi · Walter and Eliza Hall Institute of Medical Research

N. F. Jones · Walter and Eliza Hall Institute of Medical Research

Rebecca Harding · Walter and Eliza Hall Institute of Medical Research

Alistair R. D. McLean · Walter and Eliza Hall Institute of Medical Research

Abstract

The antenatal role of the hepcidin-regulating protease Tmprss6 has never been elucidated because knockout dams are infertile. Using an in vivo knockdown approach, we confirm Tmprsss6 is critical for hepcidin suppression in pregnancy, and Tmprss6 inhibition drives deleterious fetal outcomes.

Topics & Keywords

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Blood

Volume 145, Issue 25, pp. 3056-3059

DOI: 10.1182/blood.2024027563

Field-Weighted Citation Impact: 0.94