Failure of Antihypertensive Treatment to Restore Normal Sympathetic Activity

20259 citationsJournal Article

Authors

Fosca Quarti‐Trevano · Azienda Ospedaliera San Gerardo

Gino Seravalle · IRCCS Istituto Auxologico Italiano

Rita Facchetti · University of Milano-Bicocca

Konstantinos Tsioufis · Hippocration General Hospital

Kyriakos Dimitriadis · Hippocration General Hospital

Eleni Manta · Hippocration General Hospital

Giuseppe Mancia

Abstract

Thus, antihypertensive treatment, even when effective in achieving BP control, fails to restore the level of normotension-related MSNA, with a persistence of the pattern of heightened sympathetic influences typical of untreated patients with hypertension. Failure of normalization may contribute to the development of the residual cardiovascular risk reported in treated hypertensives.

Topics & Keywords

Heart Rate Variability and Autonomic Control Blood Pressure and Hypertension Studies Cardiovascular and exercise physiology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Hypertension

Volume 82, Issue 6, pp. 1024-1034

DOI: 10.1161/hypertensionaha.124.24429

Field-Weighted Citation Impact: 12.52