NaV1.5 or KCa2 channel blockade does not increase arrhythmia risk in hypokalemic rabbit hearts, unlike KV11.1 inhibition with dofetilide

20250 citationsJournal Articlegold Open Access

Authors

Yannan Yan · University of Copenhagen

Lea Abildgaard · Acesion Pharma (Denmark)

Mark Alexander Skarsfeldt · University of Copenhagen

Sofia Hammami Bomholtz · University of Copenhagen

Ulrik S. Sørensen · Acesion Pharma (Denmark)

Anders G. Holst · Acesion Pharma (Denmark)

Morten Grunnet

Abstract

These findings suggests that K<sub>Ca</sub>2 channels have minimal importance for ventricular repolarization in healthy rabbit hearts under both normo- and hypokalemic conditions.

Topics & Keywords

Cardiac electrophysiology and arrhythmias Ion channel regulation and function Cardiac Arrhythmias and Treatments

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: IJC Heart & Vasculature

Volume 59, pp. 101699-101699

DOI: 10.1016/j.ijcha.2025.101699

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