Rat embryonic stem cell-based in vitro testing platform for mammalian embryo toxicology at pre- and post-implantation stages

The RESCs-based platform allowed reproducible, robust and highly predictable results, thanks to the coupling of RESCs with high-throughput technologies. These results support the possible use of RESCs-based models as a screening platform for developmental toxicity testing to reduce the number of animals currently used for this aim.