Tandem CAR T-cells targeting CD19 and NKG2DL can overcome CD19 antigen escape in B-ALL

20255 citationsJournal Articlegold Open Access

Authors

Jennifer Bolsée · Celyad (Belgium)

Benjamin Violle · Celyad (Belgium)

Céline Jacques-Hespel · Celyad (Belgium)

Thùy Linh Nguyễn · Celyad (Belgium)

Caroline Lonez · Celyad (Belgium)

Eytan Breman · Celyad (Belgium)

Abstract

These findings provide proof-of-concept that NKG2D-based tandem CARs offer a promising approach to overcome antigen escape and enhance anti-tumor efficacy in B-cell malignancies.

Topics & Keywords

CAR-T cell therapy research Immune Cell Function and Interaction

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Frontiers in Immunology

Volume 16, pp. 1557405-1557405

DOI: 10.3389/fimmu.2025.1557405

Field-Weighted Citation Impact: 5.48