Comprehensive investigation of DNA damage repair genes in children with cancer identifies <i>SMARCAL1</i> as novel osteosarcoma predisposition gene

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Authors

Ninad Oak · St. Jude Children's Research Hospital

Wenan Chen · St. Jude Children's Research Hospital

Alise Blake · St. Jude Children's Research Hospital

Lynn Harrison · St. Jude Children's Research Hospital

Martha A. O’Brien

Christopher Previti · German Cancer Research Center

Gnanaprakash Balasubramanian · German Cancer Research Center

Abstract

Our study identifies <i>SMARCAL1</i> PV as a predisposing factor for osteosarcoma, providing insights into tumor biology and creating opportunities for development of novel therapeutic, surveillance, and preventive interventions for this aggressive childhood cancer.

Topics & Keywords

Chromatin Remodeling and Cancer Mechanisms of cancer metastasis Histone Deacetylase Inhibitors Research

Publication Details

Published in: medRxiv

DOI: 10.1101/2025.05.12.25325832

Command Palette

Comprehensive investigation of DNA damage repair genes in children with cancer identifies <i>SMARCAL1</i> as novel osteosarcoma predisposition gene

Authors

Abstract

Topics & Keywords

Publication Details