98P The miR-195-5p/CHEK1 interaction in luminal breast carcinoma: Role in progression and chemoresistance

The luminal subtype (estrogen receptor-positive, ER+) is the most common and most heterogeneous form of breast carcinoma (BC) in women. Using whole miRNome analysis followed by in silico bioinformatics approaches, we identified miR-195-5p as a candidate microRNA (miRNA) that influences the proliferation of ER+ BC, with CHEK1, CDC25A, and CCNE1 as its potential target genes. This study aimed to investigate the role of miR-195-5p and CHEK1, along with its associated genes, in the progression and chemoresistance of luminal BC patients.