Technical recommendations for analyzing oxylipins by liquid chromatography–mass spectrometry

202523 citationsReviewgreen Open Access

Authors

Nils Helge Schebb · University of Wuppertal

Nadja Kampschulte · University of Wuppertal

Gerhard Hagn · Karolinska Institutet

Kathrin Plitzko · University of Wuppertal

Sven W. Meckelmann · University of Duisburg-Essen

Soumita Ghosh · Translational Therapeutics (United States)

Robin Joshi

Abstract

Several oxylipins are potent lipid mediators that regulate diverse aspects of health and disease and whose quantitative analysis by liquid chromatography-mass spectrometry (LC-MS) presents substantial technical challenges. As members of the lipidomics community, we developed technical recommendations to ensure best practices when quantifying oxylipins by LC-MS.

Topics & Keywords

Eicosanoids and Hypertension Pharmacology Analytical Chemistry and Chromatography Metabolomics and Mass Spectrometry Studies

UN Sustainable Development Goals

Partnerships for the goals

Publication Details

Published in: Science Signaling

Volume 18, Issue 887, pp. eadw1245-eadw1245

DOI: 10.1126/scisignal.adw1245

Field-Weighted Citation Impact: 25.03