False Discovery Rate Estimation in Spectral Deconvolution in Top-down Proteomics

20250 citationsPreprintgold Open Access

Authors

Ayesha Feroz · University of Tübingen

Konstantin O. Nagornov

Tom David Müller · University of Tübingen

Timo Sachsenberg · University of Tübingen

Yury O. Tsybin · Spectroswiss (Switzerland)

Oliver Kohlbacher · University of Tübingen

Kyowon Jeong · University of Tübingen

Abstract

The complex mass spectra of entire proteins present significant challenges for data analysis in top-down proteomics (TDP). A key step in TDP analysis is spectral deconvolution, which extracts ion masses from spectral signals. Inaccuracies in this step

Topics & Keywords

Advanced Proteomics Techniques and Applications Cell Image Analysis Techniques

UN Sustainable Development Goals

Zero hunger

Publication Details

DOI: 10.22541/au.174834556.69764899/v1

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