Neuregulin 1β enhances pulmonary vein arrhythmogenesis by modulating electrophysiological characteristics, calcium and sodium homeostasis via the <scp>AKT</scp>/<scp>CaMKII</scp> pathway

20250 citationsJournal Article

Authors

Yao‐Chang Chen · Wan Fang Hospital

Wei‐Shiang Lin · Tri-Service General Hospital

Shih‐Yu Huang · Fu Jen Catholic University

Yen‐Yu Lu · Fu Jen Catholic University

Satoshi Higa · Tomishiro Central Hospital

Shih‐Ann Chen · National Chung Hsing University

Yi‐Jen Chen ·

Abstract

By modulating electrophysiological characteristics, Ca<sup>2+</sup> homeostasis, and enhancing oxidative stress through AKT/CaMKII signalling, NRG1β increased PV arrhythmogenesis with increasing RyR-dependent SR Ca<sup>2+</sup> leak of PV cardiomyocytes.

Topics & Keywords

Cardiac electrophysiology and arrhythmias Atrial Fibrillation Management and Outcomes Ion channel regulation and function

Publication Details

Published in: European Journal of Clinical Investigation

Volume 55, Issue 11, pp. e70084-e70084

DOI: 10.1111/eci.70084

Field-Weighted Citation Impact: 0.00

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Neuregulin 1β enhances pulmonary vein arrhythmogenesis by modulating electrophysiological characteristics, calcium and sodium homeostasis via the <scp>AKT</scp>/<scp>CaMKII</scp> pathway

Authors

Abstract

Topics & Keywords

Publication Details