RNA Dynamics Regulate Transcriptional Condensate Vivacity to Drive Gene Coordination

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Authors

Koichi Ogami · Nagoya University

Ming Zheng · Broad Institute

Seiko Yoshino · Nagoya University

Yohei Sugimoto · Nagoya University

Mayu Seida · Nagoya University

Toshiki Mori · Gifu University

Ryo Yoshizawa · National Cancer Institute

Abstract

RNA exosome is required for the homeostasis of transcriptional condensates (TCs)RNA synthesis and decay optimize the fluidity and dynamic properties of TCsTCs maintain the transcriptional consistency of super-enhancer (SE) genesTCs support contacts of SE-containing A compartments for coordinated transcription.

Topics & Keywords

RNA and protein synthesis mechanisms RNA Research and Splicing Genomics and Chromatin Dynamics

Publication Details

Published in: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.1101/2025.06.06.658161

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RNA Dynamics Regulate Transcriptional Condensate Vivacity to Drive Gene Coordination

Authors

Abstract

Topics & Keywords

Publication Details