Automated Diffusion Analysis for Noninvasive Prediction of <i>Isocitrate Dehydrogenase</i> Genotype in WHO Grade 2–3 Gliomas

The T2-weighted trained nnUNet algorithm achieved ADC readouts for IDH genotyping with a performance statistically equivalent to human observers. This approach could support rapid ADC-based identification of glioblastoma at an early disease stage, even with limited input data. Artificial intelligence level of evidence: 5A.