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Introduction and Objective: We previously reported that a smartphone app-based lifestyle intervention in overweight or obese subjects produced statistically significant weight loss in kg at 6 months over standard-of-care in a randomized controlled clinical trial (RCT; prespecified primary outcome) (1). The intervention included challenges during which a remote coach encouraged participants to increase step counts within a specific timeframe. We now sought to determine if the individual performances of participants in the intervention group during a single step challenge early in the 6-month RCT could predict who would successfully lose weight by the end of the trial. Methods: Methods of the RCT follow those previously published (1). We focused on the first 2-day step challenge that was unencumbered, meaning that no other challenge occurred within 7 days beforehand, nor the 7 days afterwards. For each participant, the first 2-day unencumbered challenge period was compared with a similar 2-day window 7 days earlier (pre-challenge). To assess individual engagement, objectively determined average step counts from wrist-worn accelerometers were compared between the challenge vs the pre-challenge. Results: Participants who achieved weight loss ≥5% body weight at 6 months increased their daily step counts during the first unencumbered step challenge period by 5992.6 ± 5819.9 (mean ± SE). In contrast, participants who did not achieve this degree of weight loss at 6 months decreased their daily step counts during the first challenge period by 2943.1 ± 5438.1 (t-test p=0.019). Conclusion: Successful engagement in a single step-challenge early in the trial is associated with clinically meaningful and statistically significant weight loss at 6 months. This finding can be used to better predict outcomes for participants in our technology-based remote weight loss intervention and could be used to adjust the coaching intervention to benefit early low-responders. Disclosure B. Sheridan: None. C. Deutsch: None. H. Zhao: None. K. Williams: Stock/Shareholder; Hygieia. C. Vaz: Consultant; Novo Nordisk.